|
rs121913500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Preclinical studies with an in vivo xenograft mouse model also revealed that PCa cells with the IDH1 R132H mutation have more invasive metastasis.
|
31846689 |
2020 |
|
rs772893086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Preclinical studies with an in vivo xenograft mouse model also revealed that PCa cells with the IDH1 R132H mutation have more invasive metastasis.
|
31846689 |
2020 |
|
rs112445441
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Target sequencing analysis revealed, both in primary tumor and metastasis, a pathogenic KRAS gene missense mutation c.38G > A p.(Gly13Asp) and a likely pathogenic CTNNB1 gene missense mutation c.94G > A p.(Asp32Asn).
|
31823050 |
2020 |
|
rs3918242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|
31810917 |
2019 |
|
rs121913492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Molecular analysis of the metastatic tumour demonstrated a GNAQ Q209P mutation.
|
31753826 |
2019 |
|
rs121913366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Liquid biopsy based BRAF L597Q ddPCR testing was a sensitive personalized biomarker predicting the rise of clinically aggressive metastatic disease.
|
31704811 |
2019 |
|
rs965513
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
|
rs944289
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
|
rs116909374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
|
rs966423
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most important are associations between rs966423 and mortality (HR = 1.60, p = 0.038), extrathyroidal extension (ETE) (OR = 1.57, p = 0.019); rs965513 and tumour diameter (slope of regression 0.14, p = 0.025), lymph node metastasis (OR = 1.59, p = 0.030) and ETE (OR = 1.29, p = 0.045); rs944289 and distant metastasis (OR = 0.58, p = 0.042); and rs116909374 and lymph node metastasis (OR = 0.61, p = 0.016).
|
31681970 |
2019 |
|
rs2555639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggested that the rs2555639 T allele is associated with increased risk of metastasis of colon cancer, which can be used as an indicator for colon cancer metastasis.
|
31646799 |
2020 |
|
rs1370041903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that, in one patient with pancreatic cancer, the expression of a truncated form of SPOP (p.Q360*) lacking the nuclear localization signal led to nuclear accumulation of NANOG, which promoted growth and metastasis of pancreatic cancer cells.
|
31624231 |
2019 |
|
rs7034162
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism rs7034162 was associated with metastasis of osteosarcoma in the Chinese population possibly via downregulation of <i>NFIB</i>.
|
31522615 |
2019 |
|
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>TGFB1</i> rs1800472 was positively, while rs1800470 was negatively associated with triple negativity, while rs1800470 positively correlated with menarche, but negatively with tumor size and molecular type, and rs1800469 correlated positively with menstrual irregularity, distant metastasis, nodal status, and hormonotherapy.
|
31405342 |
2019 |
|
rs1800469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>TGFB1</i> rs1800472 was positively, while rs1800470 was negatively associated with triple negativity, while rs1800470 positively correlated with menarche, but negatively with tumor size and molecular type, and rs1800469 correlated positively with menstrual irregularity, distant metastasis, nodal status, and hormonotherapy.
|
31405342 |
2019 |
|
rs664589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>In vitro</i> and <i>in vivo</i> experiments showed that the rs664589 C to G mutation facilitated carcinogenesis and metastasis of colorectal cancer.
|
31311811 |
2019 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between BRAF V600E and TERT promoter mutations and clinicopathological features, Tumor-Node-Metastasis stage, initial risk, response to therapy, follow-up, and final disease outcome were assessed according to American Thyroid Association 2015 criteria and the American Joint Committee on Cancer/Tumor-Node-Metastasis (8th edition) staging system.Median follow-up was 120 months.
|
31305897 |
2019 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between BRAF V600E and TERT promoter mutations and clinicopathological features, Tumor-Node-Metastasis stage, initial risk, response to therapy, follow-up, and final disease outcome were assessed according to American Thyroid Association 2015 criteria and the American Joint Committee on Cancer/Tumor-Node-Metastasis (8th edition) staging system.Median follow-up was 120 months.
|
31305897 |
2019 |
|
rs2227983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show that, in patients with cervical cancer, the R497K polymorphism is correlated with treatment response and the risk of recurrence or metastasis.
|
31254173 |
2019 |
|
rs3212986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate regression analysis showed that there was a significant correlation between C8092A (rs3212986) polymorphism and metastasis, grade of the tumor, and response to treatment.
|
31245210 |
2019 |
|
rs2055979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between rs2221903A/G and rs2055979G/T of the IL-21 gene and the risk of HCC and metastasis, as well as the clinico-pathological features, were analyzed.
|
31237020 |
2019 |
|
rs2221903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between rs2221903A/G and rs2055979G/T of the IL-21 gene and the risk of HCC and metastasis, as well as the clinico-pathological features, were analyzed.
|
31237020 |
2019 |
|
rs17879961
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mutations such as c.1100delC and I157T can distinguish which patients are susceptible to metastasis.
|
31220302 |
2019 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One case in a 6-year-old male was morphologically similar to the BRAF V600E mutation-positive adult cases and subsequently metastasized to the lungs; remarkably, the metastases then completely resolved on Braf targeted therapy.
|
31192863 |
2019 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One case in a 6-year-old male was morphologically similar to the BRAF V600E mutation-positive adult cases and subsequently metastasized to the lungs; remarkably, the metastases then completely resolved on Braf targeted therapy.
|
31192863 |
2019 |